This dynamic workshop will focus on safeguarding scientific integrity (SI), exploring the challenges, solutions, and ongoing efforts in promoting SI within the Canadian and the United States research and policy ecosystem. Beginning with a brief overview of the concept of scientific integrity, participants will gain insights into the historical context of SI challenges. An interactive activity will engage participants in analyzing a case study on SI violations in Canada and the US, allowing for deeper exploration and understanding of real-world challenges. Participants will leave with actionable steps to contribute to the ongoing efforts in safeguarding SI and promoting evidence-informed decision-making in policy.